Lymphatic endothelial differentiation: start out with Sox - carry on with Prox

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منابع مشابه

IL-3 induces expression of lymphatic markers Prox-1 and podoplanin in human endothelial cells.

Factors determining lymphatic differentiation in the adult organism are not yet well characterized. We have made the observation that mixed primary cultures of dermal blood endothelial cells (BEC) and lymphatic endothelial cells (LEC) grown under standard conditions change expression of markers during subculture: After passage 6, they uniformly express LEC-specific markers Prox-1 and podoplanin...

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Differentiation of lymphatic endothelial cells from embryonic stem cells on OP9 stromal cells.

OBJECTIVE The discovery of vascular endothelial growth factor C (VEGF-C) and VEGF receptor-3 (VEGFR-3) has started to provide an understanding of the molecular mechanisms of lymphangiogenesis. The homeobox gene prox1 has been proven to specify lymphatic endothelial cells (ECs) from blood ECs. We investigated the process of lymphatic EC (LEC) differentiation using embryonic stem (ES) cells. ME...

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ژورنال

عنوان ژورنال: Genome Biology

سال: 2008

ISSN: 1465-6906

DOI: 10.1186/gb-2008-9-12-243